![]() If the PROVEAN score is above the threshold, the variant is predicted to have a "neutral" effect. 2.5), the protein variant is predicted to have a "deleterious" effect. If the PROVEAN score is equal to or below a predefined threshold (e.g. The scores are then averaged within and across clusters to generate the final PROVEAN score. The top 30 clusters of closely related sequences form the supporting sequence set, which will be used to generate the prediction.Ī delta alignment score is computed for each supporting sequence. Briefly, clustering of BLAST hits is performed by CD-HIT with a parameter of 75% global sequence identity. Single or multiple amino acid deletionsĪn overview of the PROVEAN procedure is shown in Figure 1.Single or multiple amino acid insertions.Single or multiple amino acid substitutions.PROVEAN is able to provide predictions for any type of protein sequence variations including the following. PROVEAN was developed to predict whether a protein sequence variation affects protein function. The results below are based on PROVEAN v1.1. ![]()
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